Paclitaxel, sehlahisoa sa tlhaho se nkiloeng ho fir e khubelu, e thibela tumor cell mitosis ka ho sebetsa ka liprotheine tsa microtubule.Ke moemeli ea tloaelehileng oa sehlopha sa paclitaxel 'me ke lithethefatsi tsa pele tsa lik'hemik'hale tse tsoang semeleng sa tlhaho ho fumana tumello ea FDA bakeng sa phekolo ea mefuta e mengata ea kankere, ho akarelletsa le kankere ea mahe a bomme, ea matsoele, ea matšoafo, ea Kaposi's sarcoma, ea molomo oa popelo le ea pancreatic.Lilemong tsa morao tjena,paclitaxele boetse e tumme ka tšebeliso ea eona lisebelisoa tsa bongaka.A re ke re e hlahlobe sehloohong se latelang.
Lisebelisoa tsapaclitaxellisebelisoa tsa bongaka
Paclitaxel, ka nako e le 'ngoe ea polymerization e nang le α (α-tubulin) le β (β-tubulin) ea microtubulin, e etsa hore palo e kholo ea li-microtubules e be polymeri ka tsela e sa tloaelehang, e leng se fellang ka phetoho ea boemo ba skeletal equilibrium ea lisele le ho lahleheloa ke mosebetsi o tloaelehileng, ho etsa hore tsoelo-pele ea lisele e emise karolong ea G0 / G1 le karolo ea G1 le ea GM, 'me mitosis ea sele e thibeloe karolong ea mitotic, qetellong e fihlelle ho thibela karohano ea mesifa e boreleli ea vascular, ho ata Phello ke ho thibela ho arohana le ho ata ha mesifa e boreleli ea vascular. le ho thibela restenosis ho etsahala.
1. Paclitaxelstent ea lithethefatsi
Drug-eluting stent (DES) ke stent e sebelisang sethala sa tšepe se se nang letho ho jara (ho jara) sethethefatsi sa anti-endothelial proliferation, se lokolloang ke elution ea lehae ka sekepeng ho thibela ka katleho ho ata ha endothelial e le ho thibela ho fokotseha hoa mokokotlo. stent.Tšebeliso e atlehang ea li-stents-eluting stents e fokolitse haholo ts'ebetso ea ho phomola le ho kenella hape, empa ha ea ka ea fokotsa sekhahla sa ho kula le ho shoa.Ho ne ho se na liphapang tse kholo liketsahalong tsa liketsahalo tsa kliniki pakeng tsa li-stents tse hlahisang lithethefatsi, 'me lintlha tse ling tsa bobeli li ile tsa rua molemo.Li-stents tse senyang lithethefatsi li kenyelletsa li-stents tse se nang letho tse entsoeng ka tšepe e sa hloekang kapa cobalt-chromium tse koahetsoeng ka li-antiproliferative tse tsamaisang lithethefatsi tse nang le liphahlo tsa polymeric tsa phepelo ea lithethefatsi tse kenyelletsang mahlale a sa feleng, a biodegradable le a se nang polymer, 'me a na le lithethefatsi tse kenyelletsang limoxylates le paclitaxel.Hajoale, li-stents tsa lithethefatsi tsa paclitaxel li sebelisoa haholo kalafong ea mafu a fapaneng a pelo, intracranial, carotid, renal le methapo ea botšehali.
2. Libalune tse koahetsoeng ka lithethefatsi tsa Paclitaxel
Balune e koahetsoeng ke lithethefatsi (DCB), e le mokhoa o mocha le o hōlileng tsebong oa ho kenella, o 'nile oa pakoa litekong tse' maloa tsa kliniki bakeng sa katleho ea eona le tšireletseho ho ISR, liso tsa intracoronary stenosis, maqeba a likepe tse nyenyane, liso tsa bifurcation, joalo-joalo.
Tlhokomeliso: Matla a ka bang teng le lits'ebetso tse hlalositsoeng sengolong sena li tsoa ho lingoliloeng tse hatisitsoeng.
'malo o ekelitsoeng:Yunnan Hande Biotechnology Co., Ltd. esale e shebane le tlhahiso ea paclitaxel ka lilemo tse 28.Ke moetsi oa pele oa lefats'e ea ikemetseng oa sethethefatsi sa mofets'e se nkiloeng ke semela se amohetsoeng ke US FDA, European EDQM, Australian TGA, China CFDA, India, Japan le mekhatlo e meng ea taolo ea naha.khoebo.Haeba u batla ho rekaPaclitaxel API, ka kopo ikopanye le rona inthaneteng.
Nako ea poso: Oct-09-2022