Paclitaxel, motsoako oa tlhaho o nang le ts'ebetso e matla ea ho thibela mofetše, e fetohile karolo ea bohlokoa ea phekolo ea mofetše. Ntho e bitsoang taxol, e nkiloe lekhapetleng la sefate sa yew 'me ke diterpenoid alkaloid.Ka lilemo tse mashome a seng makae tse fetileng,paclitaxele bontšitse katleho e kholo kalafong ea mefuta e fapaneng ea mofetše, ho kenyeletsoa matsoele, mahe a mahe a bomme, le a mang a hlooho le a molala le a matšoafo.
Taba ea pele, ts'ebetso e khahlanong le mofets'e ea paclitaxel ke thepa ea eona ea mantlha ea pharmacological. E ka laola ka nepo kholo ea lisele tsa tumor le ho thibela ho ata le metastasis ea lihlahala ka ho thibela ts'ebetso ea unhelix ea DNA mme ka hona e thibela ho ikatisa ha DNA. e fihlelleha haholo ka ho tsitsisa tubulin, ho thibela mitosis le ho kenya apoptosis.
Litloaelong tsa bongaka, paclitaxel e sebelisitsoe haholo kalafong ea mofets'e oa matsoele. Ka kopanelo, paclitaxel e ka ntlafatsa haholo ho phela ha mokuli, ea fokotsa ho khutla hape, le ho ntlafatsa bophelo ba bakuli. Ka ho thibela ho ikatisa ha DNA ea lisele tsa tumor le ho etsa hore apoptosis e be teng, paclitaxel e khona ho laola kholo ea hlahala le ho lelefatsa bophelo ba bakuli.
Ho phaella ho kankere ea matsoele le ea mahe a bomme,paclitaxele boetse e bontšitse liphello tse ntle kalafong ea mefuta e meng ea kankere ea hlooho le molala le kankere ea matšoafo.Liphekolong tsena tsa hlahala, hangata paclitaxel e sebelisoa hammoho le lithethefatsi tse ling tse thibelang mofetše ho finyella phello e sebetsang haholoanyane ea phekolo.
Leha ho le joalo, le hoja phello ea phekolo ea paclitaxel e le ea bohlokoa, ho ka 'na ha e-ba le liphetoho tse mpe nakong ea tšebeliso. Ha u sebelisa paclitaxel, hoa hlokahala ho ela hloko ka hloko boemo ba karabelo ea bakuli, le ho kenella ka nako ea kliniki ho fokotsa karabelo e mpe.
Ka kakaretso,paclitaxele phethile karolo ea bohlokoa kalafong ea mofets'e 'me e na le ts'ebetso e kholo khahlano le mefuta e fapaneng ea lihlahala tse kotsi.Le hoja ho na le litlamorao tse mpe, ka tataiso e nepahetseng ea meriana le tlhahlobo ea bongaka, e ka fokotsa kotsi e ka bang teng le ho eketsa phello ea eona ea kalafo. tsoelo-pele ea saense le thekenoloji le kutloisiso e tebileng ea liphello tsa pharmacological tsa paclitaxel ke bafuputsi, re na le lebaka la ho lumela hore ho tla ba le lithethefatsi tse ncha le tse sebetsang haholoanyane tsa paclitaxel nakong e tlang, tse tlisang mekhoa e mengata ea phekolo le tšepo ho bakuli ba mofetše.
Tlhokomeliso: Melemo e ka bang teng le likopo tse hlahisitsoeng sehloohong sena li nkiloe lingoliloeng tse hatisitsoeng.
Nako ea poso: Nov-14-2023