Paclitaxel ke sehlahisoa sa tlhaho se ntšitsoeng lekhapetleng la sefate sa yew sa Pacific (Taxus pacifica). The biosynthesis ea paclitaxel e kenyelletsa litsela tse rarahaneng tsa biosynthetic, ho kenyelletsa le li-enzyme tse ngata le li-intermediates. phephetso tlhahisong ea 'nete ea indasteri. Mona ke kakaretso e akaretsang ea paclitaxel biosynthesis:
1.Lisebelisoa tsa ho qala: The biosynthesis ea paclitaxel e qala ka lisebelisoa tsa tlhaho tsa tlhaho, hangata ho tloha makhasi kapa makhapetla a sefate sa yew. Lisebelisoa tsena tsa ho qala li na le metsoako ea motsoali e ka sebelisoang ho kopanya li-precursors tsa paclitaxel.
2.Multi-enzyme catalysis: Biosynthesis eapaclitaxele hloka li-enzyme tse ngata ho etsa hore ho be le maikutlo.
3.Synthesis ea li-intermediates: Li-Intermediates ke mohato o ka sehloohong oa ho qaptjoa ha paclitaxel. Li na le metsoako ea polycyclic le mekhoa ea mahlakoreng a mahlakoreng a kopantsoeng butle-butle ka letoto la liketso tsa enzyme-catalyzed.
4.Final synthesis ea paclitaxel: Limolek'hule tsa pele bakeng sa motsoako oa paclitaxel butle-butle li etsoa ka limolek'hule tsa paclitaxel ka mehato e mengata ea ho itšoara.
5.Tlhahiso le tlhoekiso: Kamora ho qaptjoa ha paclitaxel, ho hlokahala mohato oa ho ntša le ho hloekisa ho arola paclitaxel e hloekileng ho tsoa ho motsoako oa karabelo.
Leha litsela tsa tlhaho tsa biosynthetic tsapaclitaxelli 'nile tsa ithutoa, tlhahiso ea sebele ea paclitaxel e ntse e le phephetso hobane e hloka motsoako o rarahaneng o nang le mehato e mengata le lisebelisoa tse ngata tse tala.Ka lebaka la mathata ana, bo-rasaense ba boetse ba batlisisa litsela tsa maiketsetso tsa ho kopanya paclitaxel e le ho eketsa chai le ho fumaneha ha eona.Synthetic synthesis ea paclitaxel hangata e kenyelletsa mokhoa o bonolo oa ho kopanya ho fokotsa ho rarahana.
Tlhokomeliso: Melemo e ka bang teng le likopo tse hlahisitsoeng sehloohong sena li nkiloe lingoliloeng tse hatisitsoeng.
Yunnan Hande Biotechnology Co., Ltd e tsepamisitse maikutlo tlhahisong ea paclitaxel ka lilemo tse 26, 'me ke moetsi ea ikemetseng oa sethethefatsi se ntšitsoeng sa mofets'e sa paclitaxel se amohetsoeng ke United States FDA,European EDQM,Australia TGA,China CFDA. ,India,Japan le mekhatlo e meng e laolang ea naha.Yunnan Hande paclitaxel,spot supply,factory direct sales, rea u amohela ho botsa,18187887160(WhatsApp the same number)
Nako ea poso: Oct-12-2023