Paclitaxel ke ntho e ntšitsoeng ho yew, e ka thibelang mofets'e ka nepo ebile ke setlhare se loantšang mofetše lefatšeng ka bophara. Lilemong tsa bo-1960, litsebi tsa k'hemistri tsa Amerika li ile tsa khetha taxol lekhapetleng la Pacific yew, semela sa Taxus. Kamora lilemo tse fetang 20 lipatlisiso tsa bongaka, ente ea pele ea paclitaxel "Taxol" e qalile ka 1992. Ho fihlela joale,paclitaxelKe e 'ngoe ea litlhare tse tsebahalang tsa botanical anti-tumor tse nang le ts'ebetso e ntle.E na le litšobotsi tsa ts'ebetso e phahameng, chefo e tlase le mefuta e mengata. E na le litlamorao tse hlakileng tsa kalafo ho mofetše oa mahe a bomme, mofets'e, melanoma e mpe, mofets'e oa matšoafo, mofetše oa senya, boko. kankere le kankere ea mala.
Liphetho tsa liteko tsa bongaka li bontša hore, hajoale, ho nkuoa hapaclitaxel APIshaholo-holo ho itšetlehile ka ho ntšoa ha limela tsa Taxus chinensis le lik'hemik'hale Semisynthesis.Bafuputsi ba saense ba bokella makala a lengoang ka mokhoa o entsoeng ka maiketsetso le makhasi a Taxus chinensis chinensis, sebelisa motsoako oa solvent, solid phase extraction,Supercritical fluid extraction,membrane separation, chromatographic separation le mekhoa e meng ea ho arohana le ho ntša ntša li-precursors tse tšoanang le sebopeho sa paclitaxel, tse kang bacatine III, 10 deacetyl bacatine III, joalo-joalo, 'me u fumane lithethefatsi tse ngata tsa bongaka tsa paclitaxel ka phetoho ea lik'hemik'hale ea mekhoa ea tlhahiso ea bongata.
Ho ea ka lipalo tsa bo-ramahlale, bakuli ba mofets'e ba hloka ho ja ligrama tse fetang 2 tsapaclitaxelka mokhoa o le mong oa phekolo. Mesaletsa ena ea paclitaxel e hloka ho ntšoa lekhapetleng la lifate tse 4-8 tsa Taxus chinensis tse seng li holile ka lilemo tse fetang 50. Ka lehlakoreng le leng, Taxus chinensis le paclitaxel ha li fumanehe, 'me ka lehlakoreng le leng Ka lehlakoreng le leng, ho na le tlhokahalo e kholo ea bongaka, e lebisang theko e phahameng ea thepa e tala ea Taxus chinensis selemo ho pota, 'me phepelo e haelloa ke tlhokahalo.
Tlhaloso: Ts'ebetso e ka bang teng le lits'ebetso tse boletsoeng sehloohong sena kaofela li tsoa lingoliloeng tse fumanehang phatlalatsa.
Katoloso ea ho bala:Yunnan Hande Bio-tech e sebetsana haholo le ho ntšoa le nts'etsopele ea taxanes.Lihlahisoa tsa eona tsa mantlha ke tsa tlhaho Paclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel, joalo-joalo Haeba u hloka ho tseba ka paclitaxel based lisebelisoa tse tala, ka kopo ikutloe u lokolohile ho ikopanya le rona ho.
Nako ea poso: Jun-14-2023