Docetaxel ke sethethefatsi se sebelisoang haholo ho phekola mefuta e fapaneng ea mofets'e, e sebetsang ka ho kena-kenana le likarolo tsa microtubule liseleng tsa mofetše. Tšobotsi ena e etsa hore docetaxel e be sebetsa se matla kalafong ea hlahala, haholo-holo maemong ao mekhoa e meng ea kalafo e sa sebetseng hantle.
I.Mechanism of Action: Ho kena-kenana le Microtubules ka Liseleng tsa Kankere
Docetaxelke ea sehlopha sa taxane sa lik'hemik'hale tsa chemotherapeutic, tse sebetsang ka ho ama likarolo tsa microtubule liseleng, ka hona li ama karohano ea lisele. Li-microtubules ke likarolo tsa bohlokoa ka har'a lisele tse bapalang karolo ea bohlokoa karohanong ea lisele, tse thusang sele ho arola lisele tse peli tse ncha. ts'ebetso e tloaelehileng ea li-microtubules tsena, tse ka thibelang kapa tsa liehisa ho hola le ho ata ha lisele tsa mofetše.
II.Ho Phekola Mafu a Mangata
Kankere ea Matsoele: Docetaxel e bapala karolo ea bohlokoa kalafong ea mofetše oa matsoele, haholo-holo maemong ao mofets'e o nang le metastasized libakeng tse ling (ka mekhahlelo e tsoetseng pele) 'me mekhoa e meng ea kalafo e hlolehile ho fana ka litholoana tse khotsofatsang.E ka thusa ho laola ho ata ha mofetše oa matsoele.
Kankere e Seng e Nyenyane ea Matšoafo ea Lisele (NSCLC): NSCLC ke e 'ngoe ea mefuta e atileng haholo ea mofets'e oa matšoafo, 'me docetaxel e sebelisoa hangata mmoho le litlhare tse ling tsa chemotherapy ho alafa maemo a tsoetseng pele kapa moo mofetše o hasaneng libakeng tse ling. Kalafo e kopaneng e ka thusa ho liehisa kholo ea lihlahala.
Kankere ea tšoelesa ea senya:Docetaxel e sebelisoa hangata kalafong ea mofetše oa tšoelesa ea senya, haholo-holo maemong ao mofetše o seng o tsoetse pele kapa mekhoa e meng ea kalafo e felile. Ho kopana ha eona le lithethefatsi tse ling ho ka ntlafatsa menyetla ea ho fumana kalafo e atlehileng.
Kankere ea Gastric (Kankere ea Mpa):Docetaxele boetse e sebelisoa ho phekola mofetše oa mala, haholo-holo bakeng sa mefuta e itseng ea kankere ea mala.Hangata e kopanngoa le lithethefatsi tse ling ho fana ka phekolo e feletseng.
Ka kakaretso,docetaxel, sethethefatsi sa chemotherapy se thibelang karohano ea lisele ka ho kena-kenana le likarolo tsa microtubule liseleng tsa mofetše, se bontšitse katleho e kholo ea phekolo ea mefuta e mengata ea kankere. tlhokomelo ea litsebi tsa bongaka ho netefatsa phello e nepahetseng ea phekolo le polokeho ea mokuli.
Tlhokomeliso: Ts'ebetso e ka bang teng le lits'ebetso tse boletsoeng sehloohong sena li tsoa ho lingoliloeng tse phatlalalitsoeng phatlalatsa.
'Malo o Eketsehileng:Yunnan Hande Biotech Co.,Ltd.e tsepamisitse maikutlo tlhahisong ea thepa e tala ea docetaxel ka lilemo tse fetang 20,' me ke eena feela moetsi ea ikemetseng oa thepa e tala ea anticancer e entsoeng ke semela e amohetsoeng ke mekhatlo e laolang joalo ka US FDA, European EDQM, TGA ea Australia, CFDA ea China, India le Japane.
Nako ea poso: Oct-26-2023