Paclitaxel ke setlhare sa bohlokoa se sebelisoang haholo kalafong ea mofets'e, empa mehloli ea eona ea tlhaho e na le moeli.Bakeng sa ho fihlela tlhoko ea paclitaxel 'marakeng oa meriana, bo-rasaense ba entse lipatlisiso tse pharaletseng,' me mekhoa ea semi-synthetic e fetoha mokhoa oa bohlokoa oa tlhahiso.Sehlooho sena se tla hlahisa mokhoa oa ho etsa semi-synthesizing paclitaxel ho tloha 10-deacetylbaccatin III (10-DAB) le ho hatisa bohlokoa ba eona tšimong ea motsoako oa lithethefatsi.
Paclitaxel, eo qalong e neng e ikarotse lekhapetleng la sefate sa yew sa Pacific, e tsebahala ka thepa ea eona e ikhethang ea ho thibela mofetše.Leha ho le joalo, yew ea Pacific ke mohloli o lekanyelitsoeng oa tlhaho, o sa lekaneng ho fihlela tlhoko ea sejoale-joale ea bongaka ea paclitaxel.Nts'etsopele ea mekhoa ea semi-synthetic e entse hore tlhahiso e kholo ea paclitaxel e khonehe, 'me 10-deacetylbaccatin III e le ea bohlokoa lipakeng.
Tokiso ea 10-DAB ho Semi-Synthetic Paclitaxel:
10-DAB ke karolo ea bohlokoa ea lipakeng tseleng ea semi-synthetic ho ea paclitaxel mme e hloka mehato e mengata bakeng sa boitokiso ba eona.Ka tloaelo, motsoako oa 10-DAB o qala ka selelekela sa tlhaho sa paclitaxel, taxuyunnanine C, e nkiloeng ho baccatin III.Baccatin III qalong e deacetylated ho hlahisa 10-deacetylbaccatin III.Ka mor'a moo, 10-deacetylbaccatin III e etsa liphetoho tse ngata, ho akarelletsa le hydrogenation, substitution, epoxidation, hydrolysis, le tse ling, qetellong e fetoha 10-DAB.
Lisebelisoa tsa 10-DAB ho Semi-Synthetic Paclitaxel:
Kakaretso ea 10-DAB e butse tsela e ncha bakeng sa semi-synthesis ea paclitaxel, e fanang ka ts'ebetso ea tlhahiso ea lithethefatsi.Paclitaxel ke moriana o thibelang mofetše o pharaletseng o sebelisoang kalafong ea mefuta e fapaneng ea mofetše, ho kenyeletsoa mofetše oa mahe a bomme, matsoele le matšoafo.Tsela ea semi-synthetic e fokotsa litšenyehelo tsa tlhahiso ea lithethefatsi, ho etsa hore khetho ena ea bohlokoa ea phekolo e fihlellehe ho bakuli.
Qetello:
Mokhoa oa semi-synthesizing paclitaxel ho tloha 10-DAB o fihletse katleho e kholo lefapheng la motsoako oa lithethefatsi.Ha e bue feela ka taba ea mehloli e fokolang ea tlhaho bakeng sa paclitaxel empa hape e ntlafatsa katleho ea tlhahiso le botsitso.Theknoloji ena e emela mohato oa bohlokoahali tlhahisong ea lithethefatsi tse thibelang mofetše 'me e na le tšepiso ea tsoelo-pele e eketsehileng lefapheng la bongaka ho loantša mafu a tebileng a kang kankere.Nakong e tlang, bafuputsi ba tla tsoela pele ho ntlafatsa mekhoa ea ho kopanya ho ntlafatsa ts'ebetso le ho fokotsa litšenyehelo, qetellong ba ruisa bakuli ba bangata.
Tlhokomeliso: Melemo e ka bang teng le litšebeliso tse boletsoeng sehloohong sena li thehiloe lingoliloeng tse fumanehang phatlalatsa.
Ho Tsoela Pele ho Bala: Yunnan Hande Biotech Co., Ltd., e nang le lilemo tse 26 e tsepamisitse maikutlo tlhahisong ea paclitaxel, ke moetsi ea ikemetseng o amohetsoeng lefatšeng ka bophara oa metsoako e sebetsang ea meriana ea anticancer paclitaxel, e ngolisitsoeng ka molao ke mekhatlo e laolang joalo ka US FDA, European EDQM. , Australia TGA, Chaena CFDA, India, Japane, le tse ling.Yunnan Hande Paclitaxel, e fumanehang setokong, e rekisoa ka kotloloho ke moetsi.Ka kopo ikutloe u lokolohile ho letsetsa lipotso ho +86 18187887160 (WhatsApp).
Nako ea poso: Oct-24-2023