Paclitaxel ke sethethefatsi se setle sa tlhaho se khahlanong le mofets'e se seng se fumanoe hajoale, se sebelisoa haholo kalafong ea mofets'e oa mahe a bomme, mofets'e oa matsoele, mofetše oa matšoafo, lihlahala tsa hlooho le molala, mofets'e oa esophageal, mofets'e oa ka mpeng le sarcoma ea lisele tse bonolo.Paclitaxele hohetse thahasello e kholo ho tsoa ho bo-ramahlale ka lebaka la sebopeho sa eona sa lik'hemik'hale tse rarahaneng le tse ncha, mekhoa e ikhethang ea ts'ebetso, ts'ebetso e tšepahalang ea ho thibela mofetše, le khaello e matla ea lisebelisoa. synthesis ea paclitaxel, 'me tlholisano e bohale haholo, e fetohileng sepheo sa chemistry ea maiketsetso ho elella bofelong ba lekholo la bo20 la lilemo.
Mokhoa o ikhethang oa anti-tumor oa paclitaxel
Paclitaxel e ka etsa hore Tubulin le Tubulin dimer tse etsang li-microtubules li lahleheloe ke tekano ea Dynamic, li khothaletse le ho khothaletsa polymerization ea Tubulin, kopano ea microtubule, le ho thibela depolymerization, e le ho tsitsisa li-microtubules le ho thibela Mitosis ea lisele tsa mofetše le ho baka apoptosis, ka tsela eo ho thibela ho ata ha mofetše. lisele le ho bapala karolo e khahlanong le mofetše.
Ha e le hantle, Tubulin, e amanang haufi-ufi le cell Mitosis, e teng hoo e batlang e le hohle ka har'a lisele tsohle tsa eukaryotic. Li ka polymerize ho li-microtubules ka mokhoa o fetohang. Karohano ea chromosome e hloka thuso ea li-microtubules tsena. ho senyeha ha hamore joalo ka li-microtubules ho ka bolaea lisele ka mokhoa o ikhethileng. Lithethefatsi tse ling tsa bohlokoa tse thibelang mofetše, joalo ka colchicine, Vinblastine, Vincristine, li bapala karolo ea anti-tumor ka ho thibela Tubulin ho re polymerization.
Ho fapana le lithethefatsi tsa anti-mitosis le anti-tumor,paclitaxelke lithethefatsi tsa pele tse fumanoang tse ka sebelisanang le polymer ea Tubulin, ke hore, e sebetsa ka ho kopanya haufi-ufi le li-microtubules ho etsa hore li tsitse.Ka nako e ts'oanang, ho fumanoa hore paclitaxel e bontša liphello tse ntle ho mefuta e sa tšoaneng ea lisele tse tiileng tsa hlahala. ho sibolloa ho hohetse litsebi tse ngata tsa baeloji ho li sebelisapaclitaxeljoalo ka sesebelisoa sa ho etsa lipatlisiso ho biomedicine, ho hlahloba likarolo tse sa tsejoeng tsa tšebetso ea lisele le ho fumana mekhoa e mecha ea lithethefatsi tse thibelang mofetše.
Tlhaloso: Ts'ebetso e ka bang teng le lits'ebetso tse boletsoeng sehloohong sena kaofela li tsoa lingoliloeng tse fumanehang phatlalatsa.
Yunnan Hande Bio-tech esale e shebane le tlhahiso ea paclitaxel ka lilemo tse 28.Ke khoebo e ikemetseng ea tlhahiso ea thepa e tala ea paclitaxel, e amohetsoeng ke mekhatlo ea taolo ea naha e kang FDA United States, EDQM Europe, TGA Australia, CFDA Chaena, India le Japane.Yunnan Handepaclitaxele fumaneha setokong mme e rekisoa ka kotloloho ke bahlahisi.Rea u amohela ho botsa.
Nako ea poso: Jun-12-2023