Paclitaxel ke motsoako oa tlhaho o ntšitsoeng semeleng sa yew, se nang le ts'ebetso ea bohlokoa e khahlanong le hlahala. Kaha paclitaxel e qalile ho aroloa lekhapetleng la Pacific yew ka 1971, lipatlisiso tsa eona mabapi le kalafo ea mofets'e e bile tse khahlang haholo. hlahloba ka botebo liphello tsa phekolo eapaclitaxelka mefuta e fapaneng ea mofetše.
Sebopeho le thepa ea paclitaxel
Paclitaxel ke motsoako o rarahaneng oa tetracyclic diterpenoid o nang le sebopeho se ikhethang sa likarolo tse tharo, se fanang ka motheo oa ts'ebetso ea eona e khahlanong le hlahala. Foromo ea eona ea molek'hule ke C47H51NO14, boima ba molek'hule ke 807.9, 'me ke phofo e khanyang ea kristale e mosehla mocheso oa kamore.
Mokhoa o khahlanong le mofetše oapaclitaxel
Mokhoa o khahlanong le mofets'e oa paclitaxel o amana haholo-holo le ho thibela tubulin depolymerization le phello ea eona ho arola lisele le ho ata. Ho feta moo, paclitaxel e ka boela ea baka apoptosis ea lisele le ho thibela tumor angiogenesis.
Phello ea kalafo ea paclitaxel mefuteng e fapaneng ea mofets'e
Mofets'e oa 1. Mofets'e: Phello ea kalafo ea paclitaxel mofetšeng oa matsoele e se e lemohuoe hohle. Phuputsong ea bakuli ba 45 ba mofetše oa matsoele, paclitaxel e kopantsoeng le chemotherapy e entse hore tumor e fokotsehe ho 41% ea bakuli le ho phela nako e fetang likhoeli tse 20.
2. Kankere ea matšoafo ea sele e seng nyane: Bakeng sa mofets'e o seng o monyane oa sele ea matšoafo, paclitaxel e kopantsoe le litlhare tsa chemotherapy tse thehiloeng ho platinum li ka ntlafatsa bophelo ba bakuli haholo. Kalafo ea lik'hemik'hale e ile ea fella ka ho phela ha likhoeli tse 12.
3. Kankere ea mahe a bomme: Kalafong ea bakuli ba 70 ba mofetše oa mahe a bomme, paclitaxel e kopantsoeng le meriana ea chemotherapy e thehiloeng ho platinum e fokolitse lihlahala ho 76% ea bakuli, 'me sekhahla sa ho phela ha lilemo tse peli se fihlile ho 38%.
4. Kankere ea 'metso:Kalafong ea bakuli ba 40 ba nang le mofetše oa mometso, paclitaxel e kopantsoeng le radiotherapy e fokolitse lihlahala ho 85% ea bakuli,' me sekhahla sa ho phela ha selemo se le seng se fihlile ho 70%.
5. Kankere ea Gastric: Ha ho phekoloa mofetše oa mala, paclitaxel e kopantsoeng le fluorouracil e ka ntlafatsa haholo bophelo ba bakuli.paclitaxelho kopantsoe le chemotherapy ho ile ha fella ka ho phela ha likhoeli tse 15.
Kalafo ea bakuli ba 30 ba mofetše oa colorectal, paclitaxel e kopantsoeng le oxaliplatin e ile ea fokotsa lihlahala ho 80% ea bakuli, 'me tekanyo ea lilemo tse peli ea ho phela e fihlile ho 40%.
7.Kankere ea sebete: Le hoja phello ea paclitaxel monotherapy ho mofetše oa sebete e lekanyelitsoe, motsoako oa lithethefatsi tse ling tsa chemotherapy tse kang cisplatin le 5-fluorouracil li ka ntlafatsa bophelo ba bakuli haholo. Ka chemotherapy e ile ea fella ka ho phela ha likhoeli tse 9.
Kankere ea liphio: Kalafong ea mofetše oa liphio, paclitaxel e kopantsoeng le lithethefatsi tse thibelang ho itšireletsa mafung tse kang interferon-alpha li ka ntlafatsa bophelo ba bakuli haholo. Likhoeli tse 24.
9.Leukemia:Ha ho phekoloa acute myeloid leukemia, paclitaxel e kopantsoeng le meriana ea chemotherapy e kang cytarabine e ka etsa hore bakuli ba fihlele tekanyo e phahameng ea tšoarelo e feletseng. ho 80% ea bakuli.
10, lymphoma:Kalafong ea non-Hodgkin lymphoma, paclitaxel e kopantsoeng le lithethefatsi tsa chemotherapy tse kang cyclophosphamide e ka thusa bakuli ho fumana tekanyo e phahameng ea karabelo e felletseng. ka karabelo e felletseng ho 85% ea bakuli.
Qetello
Ka kakaretso, paclitaxel e bontšitse katleho e itseng kalafong ea mefuta e fapaneng ea mofets'e. Leha ho le joalo, ke habohlokoa ho hlokomela hore katleho ea phekolo e fapana bakeng sa mofuta o mong le o mong oa kankere 'me hangata e hlokoa hammoho le lithethefatsi tse ling. ho rarahana le liphapang tsa motho ka mong tsa mofets'e, merero ea kalafo e lokela ho etsoa molemong oa mokuli e mong le e mong.
Tlhokomeliso: Melemo e ka bang teng le likopo tse hlahisitsoeng sehloohong sena li nkiloe lingoliloeng tse hatisitsoeng.
Nako ea poso: Nov-17-2023