Paclitaxel ke sethethefatsi se hlahang ka tlhaho se nang le ts'ebetso e kholo ea ho thibela mofets'e, se sebelisoang haholo kalafong ea mefuta e fapaneng ea mofetše. Ka tlhokahalo e ntseng e eketseha ea bongaka, ts'ebetso ea tlhahiso le theknoloji eaPaclitaxel APIli boetse li tsoela pele ho ntlafatsa.Sengoliloeng sena se tla hlahisa mokhoa oa tlhahiso le theknoloji ea Paclitaxel API ka ho qaqileng.
I.Mohloli le Tlhahiso ea Paclitaxel
Paclitaxel e tsoa haholo ho Taxus brevifolia,Taxus cuspidata,Taxus wallichiana le mefuta e meng ea Taxus.Mekhoa ea ho hula haholo-holo e kenyelletsa ho ntšoa ha solvent, ultrasonic extraction, microwave extraction,etc.Solvent extraction ke mokhoa o sebelisoang hangata, empa o na le mathata a kang nako e telele ea ho hula. le tshebediso e kgolo ya solvent.Ka lebaka leo, lilemong tsa morao tjena, bafuputsi ba 'nile ba tsoela pele ho leka mekhoa e mecha ea ho ntša, e kang enzyme hydrolysis, supercritical fluid extract, joalo-joalo, ho ntlafatsa ts'ebetso ea ho ntša le ho hloeka.
II.Ts'ebetso ea Tlhahiso ea Paclitaxel
Mokhoa oa ho belisoa bakeng sa tlhahiso ea Paclitaxel
Lilemong tsa morao tjena, mekhoa ea ho belisa e 'nile ea ithutoa haholo bakeng sa tlhahiso ea Paclitaxel.Mokhoa ona o sebelisa theknoloji ea ho belisoa ha likokoana-hloko ho hlahisa Paclitaxel ka ho lema le ho belisa lisele tsa Taxus.Mokhoa ona o na le melemo e kang potoloho e khutšoanyane ea tlhahiso, chai e ngata, le bohloeki bo phahameng. , e hloka ho ntlafatsa maemo a ho belisoa le ho hlahloba mefuta e fanang ka lihlahisoa tse ngata ho ntlafatsa katleho ea tlhahiso le ho fokotsa litšenyehelo.
Mokhoa oa ho kopanya lik'hemik'hale bakeng sa tlhahiso ea Paclitaxel
Chemical synthesis ke mokhoa o mong oa bohlokoa bakeng sa tlhahiso ea Paclitaxel.Mokhoa ona o sebelisa theknoloji ea organic synthesis ho kopanya Paclitaxel ka litsela tsa lik'hemik'hale tsa lik'hemik'hale. litšenyehelo tse phahameng, tse fokotsang tšebeliso ea eona e sebetsang.
Motsoako oa tlhahiso ea tlhaho le motsoako oa lik'hemik'hale ts'ebetsong ea tlhahiso
E le ho hlōla mefokolo ea mekhoa e le 'ngoe ea tlhahiso, bafuputsi ba ntse ba hlahloba motsoako oa tlhaho ea tlhaho le motsoako oa lik'hemik'hale nakong ea tlhahiso.Mokhoa ona o qala ka ho ntša lintho tse tlang pele ho Paclitaxel ho tloha mefuteng ea Taxus ho sebelisa motsoako oa solvent, ebe o li fetolela Paclitaxel ho sebelisa lik'hemik'hale tsa lik'hemik'hale. theknoloji.Mokhoa ona o kopanya melemo ea tlhaho ea tlhaho le motsoako oa lik'hemik'hale, o ntlafatsa katleho ea tlhahiso le bohloeki, 'me o fokotsa litšenyehelo tsa tlhahiso.
III.Mathata le Litaelo tsa Ntlafatso ho Theknoloji ea Tlhahiso ea Paclitaxel
Ho ntlafatsa ts'ebetso le bohloeki ba ho ntšoa: Ho nts'etsapele mekhoa le mahlale a mahlale a ho ntša metsi a macha, li-enzyme tse kopantsoeng, joalo-joalo, ho ntlafatsa ts'ebetso le bohloeki ba Paclitaxel.
Ho ntlafatsa maemo a ho belisoa le ho hlahloba mefuta e behang haholo: Ho ntlafatsa maemo a ho belisoa (joalo ka sebopeho se mahareng, mocheso, pH ea boleng, joalo-joalo) le ho hlahloba mefuta e behang haholo ho eketsa chai le bohloeki ba tlhahiso ea Paclitaxel e thehiloeng ho belisoa.
Ho fokotsa litšenyehelo tsa tlhahiso: Ho hlahisa lisebelisoa tse ncha tse tala, ho ntlafatsa mekhoa ea tlhahiso, le ho finyella tlhahiso e kholo ho fokotsa litšenyehelo tsa tlhahiso ea Paclitaxel le ho ntlafatsa tlhōlisano ea 'maraka.
Ho matlafatsa taolo ea boleng: Ho theha sistimi e felletseng ea taolo ea boleng ho laola ka tieo boleng ba lisebelisoa tse tala, lits'ebetso tsa tlhahiso, le lihlahisoa ka taolo e matla ea boleng le tlhahlobo ea tlhahlobo ho netefatsa boleng ba sehlahisoa le polokeho.
Ho nts'etsapele mekhoa e mecha: Ho nts'etsapele libopeho tse ncha (joalo ka li-nanomaterials, liposome formulations, joalo-joalo) ho ntlafatsa bioavailability le katleho ea Paclitaxel in vivo ho ipapisitse le mefokolo ea eona ea ts'ebeliso ea bongaka.
Ho holisa masimo a ts'ebeliso: Ho holisa le ho feta masimo a ts'ebeliso ea Paclitaxel ho feta kalafo ea mofets'e (joalo ka anti-inflammatory, antioxidant effects), ho fana ka litlamorao tse pharalletseng tsa pharmacological le boleng ba ts'ebeliso.
IV.Qetello le Ditebello
Ka tsoelopele e tsoelang pele ea mahlale le thekenoloji le tlhokahalo e ntseng e eketseha ea bongaka eaPaclitaxel APINakong e tlang, bafuputsi ba tla tsoelapele ho hlahloba mekhoa e mecha ea tlhahiso le mekhoa ea theknoloji ho ntlafatsa katleho ea tlhahiso ea Paclitaxel, ho fokotsa litšenyehelo tsa tlhahiso, ho atolosa masimo a kopo, le ho fana ka liphallelo tse ngata. ho bophelo bo botle ba batho.
Tlhokomeliso: Ts'ebetso e ka bang teng le lits'ebetso tse boletsoeng sehloohong sena li tsoa ho lingoliloeng tse phatlalalitsoeng phatlalatsa.
Nako ea poso: Dec-13-2023