Sesebediswa Meriana
Paclitaxel, joalo ka sethethefatsi sa mofetše, e sebelisoa haholo Lienteng le Lisebelisoa tse fapaneng.
Haholo-holo e entsoe ka ho ntšoa ha tlhaho le ho kopanya.
Joalo ka mohloli oa semela oa paclitaxel e nkiloeng ka tlhaho, Taxus Chinensis, e batla e haella ebile e na le potoloho e telele ea kholo, letoto la mekhoa ea ho kopanya e nkiloe butle ho tloha paclitaxel ka lipatlisiso le liteko ho pota lefatše, ho kenyeletsoa kakaretso ea synthesis, semi-synthesis, le motsoako oa endophytic.
Ka lebaka la tsela e telele ea ho kopanya lik'hemik'hale, mehato e mengata ea ho kopanya, 'me ho le thata ho laola maemo a karabelo, paclitaxel e entsoeng ka botlalo e hloka ho sebelisa li-reagents tsa lik'hemik'hale tse theko e boima haholo,' me lihlahisoa le tsona li tlaase, tse sa lokelang bakeng sa tlhahiso ea bongata le tlhahiso ea indasteri. kakaretso.
Ka hona, palo e batlang e le ngata ea paclitaxel 'marakeng hangata e etsoa ke ho ntšoa ha tlhaho ha taxus e lenngoeng le mekhoa ea semi-synthetic.
Natural Paclitaxel vs Semi-synthetic Paclitaxel
Karolo ea 1: Ts'ebetso ea Tlhahiso
- Lintho tse tala: Yew e lenngoeng ka maiketsetso
-Ts'ebetso ea ho ntša: thepa e tala+kholomo chromatography+recrystallization=sehlahisoa se felileng
-Ts'ebetso ea ho ntša: karabelo ea 'mele, ha ho na ts'ebetso ea motsoako oa lik'hemik'hale
- Lintho tse tala: Yew e lenngoeng ka maiketsetso
-Ts'ebetso ea ho ntša: lisebelisoa tse tala+ lik'hemik'hale tsa reagent reaction+concentrated crystallization+liphetoho tse fapaneng tsa lik'hemik'hale+recrystallization = sehlahisoa se felileng
-Ts'ebetso ea ho ntša: karabelo ea lik'hemik'hale
Mabapi le theknoloji, paclitaxel ea tlhaho e na le mehato e bonolo ea ho hula ha e bapisoa le semi-synthetic paclitaxel le melemo e mengata ho feta semi-synthetic paclitaxel mabapi le botsitso le polokeho, athe semi-synthetic paclitaxel e fokotsa litšenyehelo tsa nts'etsopele ea sehlahisoa ho latela litšenyehelo le lisebelisoa tse tala. , hape e ntlafatsa mathata a mang a bakoang ke khaello ea thepa e tala 'marakeng.
Ha ho bapisoa le mekhoa e 'meli ea ho hlahisa paclitaxel, paclitaxel ea tlhaho e na le botsitso bo betere le polokeho lisebelisoa tsa bongaka, e leng lebaka le leng leo ka lona lik'hamphani tse ngata tsa lisebelisoa tsa bongaka 'marakeng li sebelisang paclitaxel ea tlhaho e le lisebelisoa tse tala.
Yunnan Hande Biotechnology Co.,Ltd.e sebelitse ka lilemo tse 30 ho ntšoa le ho nts'etsapele makhetho,' me lihlahisoa tsa eona tsa mantlha ke paclitaxel,10-DAB semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel, joalo-joalo. lintlha tse ling mabapi le li-API tsa paclitaxel, ka kopo ikopanye le rona !!!(Whatsapp/Wechat:+86 18187887160)
Nako ea poso: Jan-17-2023