Paclitaxel, motsoako oa tlhaho o tsoang sefateng sa Yew, e 'nile ea fetola papali ea phekolo ea kankere ka lilemo tse mashome.Leha ho le joalo, ho fumaneha ho fokolang le litšenyehelo tse phahameng tsa ho ntša paclitaxel lifateng tsa yew li entse hore bo-rasaense ba hlahise mekhoa e meng.Ho fihla ha 10- deacetylbaccatin III (10-DAB) semi-synthetic paclitaxel API, phofo e tšoeu e nkiloeng mehloling ea limela e tsosolositsoeng, e butse menyetla e mecha tšimong ea oncology. phekolo.
Boteng bo Ntlafetseng le Moshoelella:
The synthesis of paclitaxel from10-DABe fana ka tharollo ea moshoelella mefokolong ea ho ntšoa ha sefate sa yew.Mekhoa ea setso e kotuloa paclitaxel ho tloha lekhapetleng la yew, e bakang mathata a tikoloho le phepelo e thibetsoeng. Ho fapana le hoo, ts'ebetso ea semi-synthetic e sebelisang 10-DAB e lumella tlhahiso e kholo, ho netefatsa botsitso bo tsitsitseng. le phepelo e tsitsitseng ea moriana ona oa bohlokoa.Katleho ena ha e sebetsane le mathata a tikoloho feela empa e boetse e ntlafatsa boteng ba paclitaxel bakeng sa bakuli lefatšeng ka bophara.
Katleho ea Litšenyehelo:
Tsoelopele ea10-DAB semi-synthetic paclitaxel APIe na le monyetla oa ho fokotsa litšenyehelo tsa kalafo ea mofets'e haholo.The scalability and cost-effective process of the production process kenya letsoho hore ho be le meriana e theko e tlaase le e fihlellehang, ho bebofatsa moroalo oa lichelete ho bakuli le lits'ebetso tsa tlhokomelo ea bophelo. Phihlello ena e bula menyako bakeng sa phihlello e pharaletseng ea mokuli ho liphekolo tse pholosang bophelo, qetellong li ntlafatsa sephetho le litekanyetso tsa ho pholoha.
Lisebelisoa tse Atolositsoeng tsa Kalafo:
Ka ntle ho karolo ea eona e thehiloeng ho alafeng mofetše oa matsoele, oa mahe le oa matšoafo,10-DAB semi-synthetic paclitaxel APIe fana ka menyetla e thabisang ea ho hlahloba lits'ebetso tse ncha tsa kalafo.Bafuputsi ba ka batlisisa katleho ea eona mefuteng e fapaneng ea mofets'e, ka monyetla oa ho atolosa tšebeliso ea eona ho mafu a neng a sa phekolehe pele.Ho feta moo, motsoako oa 10-DAB paclitaxel le li-anti-cancer tse ling li ka hlahisa litlamorao, tsa ntlafatsa kalafo. liphetho le ho fokotsa khanyetso ea lithethefatsi.
Meriana e Ikemetseng le Oncology e Nepahetseng:
Ka ho fumaneha ha 10-DAB semi-synthetic paclitaxel API, meriana e ikemetseng le oncology e nepahetseng e ka hatela pele. ho fokotsa litla-morao.Ho feto-fetoha ha 10-DAB paclitaxel API ho lumella mekhoa ea phekolo e ikhethileng, ho matlafatsa lingaka ho fana ka litlhare tse lebisitsoeng ka ho nepahala ho ntlafetseng.
Qetello:
Kenyelletso ea10-DAB semi-synthetic paclitaxel APIe tšoaea mohato oa bohlokoa lefapheng la kalafo ea mofets'e. Phofo ena e tšoeu e fana ka boteng bo ntlafetseng, bo tsitsitseng, le ts'ebeliso ea litšenyehelo, ho fetola mokhoa oa ho fumaneha ha paclitaxel. ho fetola boemo ba tlhokomelo ea mofets'e. Ha lipatlisiso le nts'etsopele sebakeng sena li ntse li tsoela pele, bokamoso ba kalafo ea mofets'e bo khanya haholoanyane ka melemo e ka bang teng ea boqapi bona bo tsotehang.
Nako ea poso: May-17-2023